Glymphatics, SAH, and Cognitive Outcomes

Glymphatic System and Cognitive Outcomes after SAH

medical-cross
Subarachnoid hemorrhage
user
All genders
person-wave 18-100
world
Recruiting now

Overview
Principal Investigator: Sarah Nelson

(This is not a clinical trial.) The glymphatic system, a brain-wide fluid transport mechanism, permits brain waste clearance, and disruption of this system can occur in subarachnoid hemorrhage (SAH). A special MRI sequence can reflect impaired glymphatic transport and has been associated with poor functional outcomes in aneurysmal SAH patients but the cognitive effects of glymphatic disruption are not well-studied. In this study, we will perform the a special MRI sequence to evaluate the glymphatic system in aneurysmal SAH patients then evaluate cognitive deficits via 2 validated telephone-based scales at 6 months. 

Study details
Inclusion Criteria
  • Age 18-120 years old
  • Diagnosis of aneurysmal SAH of any grade
  • Subjects must be scheduled or planned to undergo an MRI to qualify for the study (to ensure that an MRI is not conducted for the purposes of this study).
Exclusion Criteria
  • Age <18 years old
  • Non-aneurysmal SAH
  • Patient is pregnant.
Study Requirements

Extra 10-minute MRI sequence
Phone call (lasting 30 minutes or less) to undergo 2 cognitive tests 6 months after MRI