A placebo-controlled, double-blind randomized trial of short course intravenous corticosteroids for patients with acute respiratory failure who require mechanical ventilation for more than 48 hours withFiberoptic Endoscope Evaluation of Swallowing (FEES) documented laryngeal edema.
Corticosteroids for Post-Extubation Aspiration
Randomized Trial of Corticosteroids for Post-Extubation Aspiration
Pulmonary hypertension
All genders
18-100
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Overview
Principal Investigator: Nicholas Hill, MD
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Mary Hays
Study details
Inclusion Criteria
- Participant enrolled in primary study COMIRB #21-3873/ NCT # 05108896
- Laryngeal edema identified on participants primary study Fiberoptic Endoscopic Evaluation of Swallowing (FEES) as defined as a revised Patterson edema score greater than zero
- Admission to an ICU during their hospitalization
Exclusion Criteria
- Patient, appropriate surrogate/proxy, or provider refusal
- Contraindication to corticosteroids defined as an allergic reaction (extremely rare) or taking other
immunosuppressive medications. - Chronic treatment with corticosteroids as defined as Prednisone >40 mg/day or methylprednisolone 32 mg/day
Study Requirements
Subjects will be in the hospital so there will be no outpatient research visits. The study is performed over 48 hour period while subject is in the hospital. As the focus is on laryngeal edema and swallowing function, there are no blood collections. There are no x-rays, CT scans or MRIs.