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TAP Block and minimally invasive hysterectomy for pain control

A randomized, controlled, observer-blinded pilot trial of laparoscopic large volume, multisite transversus abdominal plane (TAP) block with liposomal bupivacaine in patients undergoing minimally invasive hysterectomy for endometrial cancer

Uterine cancer
person-wave 18-80
Recruiting now
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Principal Investigator: Young Kim, MD

In this study, researchers are hoping to improve post-operative pain control and reduce opioid use using a technique called TAP block. A TAP block is a form of pain relief that "blocks" the pain receptors in a person's abdomen and can be performed during minimally invasive hysterectomy. Enrolled participants undergoing minimally invasive hysterectomy will be randomized to three pain control or TAP block options. The three arms are TAP block with liposomal bupivacaine plus plain bupivicaine, TAP block with plain bupivacaine alone, and standard care (meaning no TAP block is performed during surgery, but pain control is available via NSAIDs and acetominophen). Participants and the nurses doing the post-operative phone surveys will not know which arm they were randomized to in order for the study surgeons to gather unbiased results.

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Alysa St. Charles

Study details

Inclusion Criteria
  • 1. Age 18-80
  • 2. Patients undergoing laparoscopic or robotic hysterectomy; may include other procedures (e.g. lymph node removal)
  • 3. Endometrial cancer or endometrial intraepithelial neoplasia
Exclusion Criteria
  • 1. Known clinically significant allergy to bupivacaine or liposomal bupivacaine
  • 2. Current chronic opiate use or other chronic pain medication use
  • 3. Severe hepatic or renal impairment
Study Requirements

Each participant will be in this study for 7 days. Phone surveys will be done on post-op days 1, 2, 3, and 7 to collect pain reports on a scale of 1-10. Participants will also be asked a short satisfaction survey with pain control on post-op day 7 and will be asked how many opiate pills they took for breakthrough pain.

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