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Mepi vs. Bupi in Neurosurgery

Mepivacaine versus bupivacaine for neurosurgical procedures

Back pain
All genders
person-wave 18-99
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Principal Investigator: Lindsay Gittens

Researchers at Tufts Medical Center are conducting a study on the benefits of mepivacaine in neuraxial anesthesia for certain neurosurgical procedures. The purpose of this study is to see if mepivacaine, a local anesthetic, can shorten your time in the recovery room/hospital; decrease the amount of time before you can walk after surgery; allow you to urinate sooner after surgery; and reduce any nausea and vomiting that you might experience after anesthesia and surgery.

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Lindsay Gittens

Study details

Inclusion Criteria
  • Older than 18 years of age at the time of their surgery
  • Booked to have either a single-level transforaminal lumbar interbody fusion (TLIF) or single-or multiple-level laminectomies
  • Able to receive neuraxial anesthesia safely
Exclusion Criteria
  • Less than 18 years of age
  • Not a candidate for neuraxial anesthesia
  • Unable to give consent on your own
Study Requirements

The study will require data collection of your progress after surgery in the recovery room. In addition, you will be asked questions by research assistants regarding the following: level of pain (on a 1-10 point scale); any nausea/vomiting; dizziness/lightheadedness; and bladder pain. The research assistants will also collect information about the medicines that you are receiving in the recovery room. Your participation ends when you are discharged from the hospital. No follow-up is required, other than routine post-operative follow-up as directed by your neurosurgeon. 

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