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Lifestyle Intervention in Preparation for Pregnancy (LIPP)

Obesity, Pregnancy
person-wave 18-45
Recruiting now
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Principal Investigator: Patrick M. Catalano, MD

The aim of this study is to improve the metabolic health of overweight and obese women prior to a planned pregnancy.

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Patrick M. Catalano, MD

Study details

Inclusion Criteria
  • Planning a pregnancy
  • BMI between 25 - 35
  • Willing to participate in physical activity and healthy eating
Exclusion Criteria
  • Males
  • Women of non-childbearing age
  • BMI <25 or >35
Study Requirements
  • Laboratory blood sample will be taken for routine laboratory studies - blood count, hemoglobin, A1c, thyroid, liver and kidney function studies, and a lipid profile including cholesterol, triglycerids, and HDL. The total amount of blood drawn for the first visit will be 100mL or about 7 tablespoons.
  • Indirect calorimetry for 30 minutes to determine resting metabolic rate. A clear plastic hood will be placed over the subject's head; the hood allows fresh air to flow in while a tube sends the out breath air into an instrument that measures oxygen and carbon dioxide.
  • Urine specimens.
  • Oral glucose tolerance test from blood samples (6 tablespoons) that will be obtained for fasting blood glucose (sugar) levels, followed by drinking an orange-flavored beverage that contains a known amount of glucose (sugar). Samples will be obtained at baseline 30, 60, 90, 120 and 180 minutes.
  • Body composition measurements and exercise capacity test.
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