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C2D2AI Participant Recruitment Feasibility Study

C2D2AI Participant Recruitment Feasibility Study

Cerebrovascular disease
All genders
person-wave 50+
Recruiting now


Principal Investigator: David M Kent

Broadly, the purpose of this project is to evaluate the baseline stroke and dementia risk of those Indvidual identified by NLP and characterize the population identified during the recruitment process through enrollment. Additionally, we seek to assess changes to medical care and medications in the 90-days after being informed of the NLP findings. We will use this study to assess overall study feasibility work with the goal of being able to provide metrics, in this population, of rates of agreement to research and interest in a future interventional study, as well as explore opportunities to expand recruitment of driskiverse individuals and develop best practices for recruiting and retaining this population. Findings from this study will be used as the basis of developing an interventional clinical trial seeking preventive therapies for stroke and dementia in this population.

Study details

Inclusion Criteria
  • 1) At risk for stroke and dementia as identified by a natural language processing algorithm
    programmed to screen radiology reports of head CTs and MRIs for presence of white matter disease
    and/or covert brain infarction.
  • 2) Age greater than 50 years
  • 3) Provision of signed and dated written informed consent prior to any study procedures
Exclusion Criteria
  • 1) Prior history of Stroke or transient ischemic attack, Dementia or cognitive decline [any EMR
    evidence – indicative ICD9 codes], Brain tumor, intracranial hemorrhage, or other condition that
    impedes outcome assessment.
  • 2) MRI or head CT where covert cerebrovascular disease was identified was ordered for suspicion of
    Stroke or transient ischemic attack, Dementia or cognitive decline
  • 3) Patient is determined by clinical evaluation or questionnaire administration to not be free of
    symptomatic stroke or cognitive decline
Study Requirements

Participants will be enrolled into the study and followed for 90 days. The screening/baseline visit will last approximately 2 hours. The 90-day encounter will be conducted over the phone/video and will last approximately an hour. These participants will be recruited from the patient populations of the participating institutions who have received neuroimaging and have been identified by the Natural Language Processing (NLP) algorithm as having white matter diease (WMD) and/or covert brain infarction (CBI).

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